📋 Tender Overview
Total cost € 2 143 826,00
In Vivo Imaging Genesis And Circuit Integration Of Interneurons Engineered From Glia
Reprogramming Nervous System Cell Identity And Remodelling The Diseased Brain Circuitscell Identity Reprogramming In The Nervous System Offers The Prospect Of Remodelling Diseased Brain Circuits. Recent Studies Have Demonstrated The Conversion Of The Brain Glial Cells Into Neurons In Vivo. However, It Is Unclear How The Converted Neurons May Integrate Into Pre-Existing Circuits And If They Can Participate In Cortical Information Processing And Restore Dysfunctional Cortical Circuits. Previously, The Project Discovered A Combination Of Reprogramming Factors To Induce Fast-Spiking, Parvalbumin Expressing Interneurons, Which Are Vulnerable In Neuropsychiatric And Neurological Disorders. The Eu-Funded Imagine Project Aims To Visualise The Conversion Of Glial Cells Into Induced Interneurons In Real Time Using In Vivo Imaging. The Study Will Test The Induced Interneurons For Their Ability To Rescue Excitation-To-Inhibition Balance In A Mouse Model Of Endogenous Interneuron Dysfunction.
Funded Under
Excellent Science - European Research Council (Erc)
Total Cost
€ 2 143 826,00
Eu Contribution
€ 2 143 826,00
Coordinated By
King~S College London
United Kingdom
