📋 Tender Overview
Understanding The Pan-Immune System Of Bacteria
Multiple Anti-Phage Defence Systems In Bacteriathe Arms Race Between Bacteria And Phages Resulted In The Creation Of Efficient Anti-Phage Systems, Including Restriction Enzymes And Crispr-Cas, Which Also Presented Invaluable Molecular Genetics Tools. Recent Discoveries Of Additional Bacterial Defence Systems Included The Cyclic-Oligonucleotide-Based Anti-Phage Signalling Systems (Cbass) And Prokaryotic Viperins And Were Based On The Observation That They Are Clustered Into Defence Islands In Bacterial Genomes. The Preliminary Results Suggest That Many Anti-Phage Systems Remain Undiscovered In Microbial Defence Islands. The Eu-Funded Defenseagainstphage Project Aims To Discover, Validate And Study The Properties Of New Systems And The Mechanisms Used By Phages To Overcome The Defence. Discovering The New Systems Could Yield Not Only An Understanding Of The Phages-Bacteria Interactions But Also New And Exciting Molecular Tools.
Funded Under
Excellent Science - European Research Council (Erc)
Total Cost
€ 2 500 000,00
Eu Contribution
€ 2 500 000,00
Coordinated By
Weizmann Institute Of Science
Israel
