📋 Tender Overview
Toward A Comprehensive Analysis Of The Dynamics And Mechanisms Of X Chromosome Inactivation In Humans
X Chromosome Inactivation In Humansthe Process Of X Chromosome Inactivation (Xci), I.E. The Stable, Yet Reversible Silencing Of One Of The Two X Chromosomes, Is Critical For Female Development And Linked To Sex-Specific Traits And Susceptibilities To Various Diseases. Current Knowledge Of Xci Dynamics And Control In Humans Is Limited, Despite Major Implications For Human Health. The Eu-Funded Xcycle Project Aims To Elucidate The Molecular And Cellular Mechanisms Of Human Xci To Further Understand Human Development And Sex-Specific Diseases. Xcycle Will Use Human Embryonic Stem Cells And The Latest Culture Methods To Mimic The Early Stages Of Development And Organogenesis, Allowing An Understanding Of The Phases Preceding Xci, Its Initiation, Maintenance In Tissues, And Its Reversion In The Germline.
Funded Under
Excellent Science - European Research Council (Erc)
Total Cost
€ 2 499 930,00
Eu Contribution
€ 2 499 930,00
Coordinated By
Centre National De La Recherche Scientifique Cnrs
France
