📋 Tender Overview
Targeting Long Non-Coding Rnas For Novel Treatment Strategies In Vascular Diseases
Long Non-Coding Rnas As Potential Therapeutic Targets In Vascular Diseasesnucleic Acid-Based Therapies Are Emerging As Treatment Options For Many Diseases. The Majority Of The Human Genome Is Transcribed Into Non-Coding Rnas, Including More Than 15 000 Long Non-Coding Rnas (Lncrnas). Targeting Lncrnas Via Rna Interference Strategies Provides Opportunities To Modulate Cellular Processes. The Goal Of The Erc-Funded Longtx Project Is To Identify Lncrnas Involved In Vascular Disease Development As Potential Therapeutic Targets. Profiling Of The Diseased Human Tissue From Patients With Carotid Artery Disease, Stroke, And Abdominal Aortic Aneurysms Led To The Identification Of Two Suitable Lncrnas. The Project Objectives Are To Study These Lncrnas In The Preclinical Arteries-On-Chips Model And In Vivo In Genetically Modified Animal Models, Focusing On Efficient Delivery Of Antisense Oligonucleotide Inhibitors To Target These Transcripts.
Funded Under
European Research Council (Erc)
Total Cost
€ 1 999 495,00
Eu Contribution
€ 1 999 495,00
Coordinated By
Klinikum Rechts Der Isar Der Technischen Universitat Munchen
Germany
