📋 Tender Overview
Tackling Functional Maturation For Transplantable Hematopoietic Stem Cell Generation
Objective
Hematopoietic stem cells (HSC) provide a lifelong supply of blood and immune cells. They are a life-saving therapy for leukemia and have recently found broadened applications to gene and cell therapy, against other cancers, genetic, autoimmune, and infectious diseases. Nonetheless, practical limitations, such as donor-matching or insufficient cell number render these therapies unfeasible or unsuccessful for many patients. Attempts to overcome these limitations have been unable to create a reliable source of HSC for patients: while we can generate human HSC from pluripotent stem cells (PSC), they resemble early development stages, lacking the functional maturation hallmarks.
Funded Under
European Research Council (Erc)
Total Cost
€ 2 265 684,00
Eu Contribution
€ 2 265 684,00
Coordinated By
Fundacio Institut De Recerca Contra La Leucemia Josep Carreras
Spain
