📋 Tender Overview
In-Situ Spatiotemporal Imaging Of Membrane Hydration, Electrostatics, Tension And Curvature To Understand Cell Response To Osmotic Shocks And Cell Migration.
Revealing Unknown Processes In Lipid Membraneslipid Membranes Are Self-Assembled Viscoelastic Bilayers With Unique Characteristics (Deformability, Fluidity, Resistance For Stress Or Stretching, And Chemical Complexity) Allowing Them To Separate And Protect Cells From The Environment, While They Selectively Enable Transport, Which Makes Them Crucial For The Life Of Cells. However, Their Mechanical Properties In Several Important Cell Processes Remain Unknown. In This Context, The Eu-Funded R2-Tension Project Will Study Dynamics Of Water Fluxes, Curvature And Tension In Cellular Membranes To Elucidate Quantitatively The Coupling Between Cell Volume And Membrane Tension In Single Cells During Osmotic Shocks. The Team Will Use In Situ Spatiotemporal Imaging Of Membrane Hydration, Electrostatics, Tension And Curvature. The Developments Will Be Essential For The Treatment Of Cancer And Other Cellular Disorders.
Funded Under
Excellent Science - European Research Council (Erc)
Total Cost
€ 4 947 465,00
Eu Contribution
€ 4 947 465,00
Coordinated By
Ecole Polytechnique Federale De Lausanne
Switzerland
