📋 Tender Overview
The Sex-Dependent Effects Of Amino Acid-Based Diets On Energy Metabolism: Innovative Approaches To Manage The Metabolic Syndrome
Funded Under
Marie Sklodowska-Curie Actions (Msca)
Total Cost
€ 0,00
Eu Contribution
€ 336 006,72
Coordinated By
Universita Degli Studi Di Milano
Italy
Objective
The stimulation of brown adipose tissue (BAT) thermogenesis and energy expenditure has gained prominence in the management of obesity and type 2 diabetes. In this context, I propose innovative nutritional strategies as efficient tools to promote BAT thermogenic program, with therapeutic effects on obesity, type 2 diabetes, and metabolic syndrome (MetS). There are four aims. Aim 1 focuses on the sex-based efficacy of essential amino acid (EAA)-based supplements and designer diets in the animal models of diet-induced obesity and in the chronic subordination stress model of MetS. I investigate whether and how sex differences influence BAT thermogenesis activation induced by nutritional challenges and the role of the sympathetic nervous system (BAT-denervated, ß-less mice, optogenetic methods to evaluate the ability of diets/supplements to increase the SNS capacity). Aim 2 characterizes the role of BAT as a secretory organ, using state-of-the-art techniques (transcriptomics, metabolomics, BAT ablation/transplantation). Aim 3 studies the sex-based beneficial effects of supplements in men and women with severe obesity. Aim 4 relates to the additional non-academic placement period in Professional Dietetics, a company with a strong background in developing amino acid-based formulas for medical use, to acquire knowledge about patent management and regulatory affairs in the healthcare industry.
