📋 Tender Overview
Setting The Optimal Balance Between Metabolite Supplementation And Deprivation In Cancer Therapy
Objective
The goal of this proposal is to explore combinations of targeted metabolite supplementation and global nutrient restriction as a new strategy to reprogram tumor metabolism, to halt tumor progression and to improve response to treatments.
Preclinical and clinical studies published by our group and by others showed that global nutrient restriction, in the form of cyclic fasting or fasting-mimicking diets (FMDs), produces desirable metabolic and immunologic effects that result in reduced tumor progression and in the prolongation of animal/patient survival. Of note, our unpublished results indicate that the supplementation of specific amino acids or fatty acids has in vitro and in vivo antitumor effects, which are strongly enhanced when metabolite supplementation is combined with nutrient starvation.
Funded Under
European Research Council (Erc)
Total Cost
€ 1 499 250,00
Eu Contribution
€ 1 499 250,00
Coordinated By
Ifom-Istituto Fondazione Di Oncologia Molecolare Ets
Italy
