📋 Tender Overview
Rewire The Lymph Node Niche To Instruct T Cell Immunity
Lymph nodes (LN) are communication centers within the lymphatic network that instruct T cell priming and differentiation in homeostasis and disease. Multiple layers of control are achieved by a complex network of signals from stromal and immune cell compartments. As a result, spatially segregated LN niches coexist that foster diverse T cell lineages. In the context of cancer, T cell differentiation is pushed towards the lineage of exhaustion, with a progenitor exhausted T cell population arising in the LN. Hence, LN are central anatomic sites where T cell exhaustion can be controlled and reversed to eliminate cancer. The key question of REWIRE is: What microenvironmental factors determine the differentiation and maintenance of progenitor exhausted T cells in the LN?
Funded Under
European Research Council (Erc)
Total Cost
€ 1 499 730,00
Eu Contribution
€ 1 499 730,00
Coordinated By
Cemm - Forschungszentrum Fuer Molekulare Medizin Gmbh
Austria
