📋 Tender Overview
Overcoming Resistance To Immunotherapy: Immunostimulatory Tumor-Derived Extracellular Vesicles As Multifunctional Anticancer Agents
Cell-Free Tumour-Derived Immunotherapyextracellular Vesicles (Evs) Are Cell-Secreted Particles Employed For Cell-To-Cell Communication And Delivery Metabolites, Proteins, Lipids, And Nucleic Acids. Although Tumour-Derived Evs (Tex) Are Known For Their Immunosuppressive Function, Emerging Evidence Suggests That Cancer Cells Can Modulate The Biogenesis And Content Of Tex, Potentially Altering Their Impact On The Immune System. Funded By The European Research Council, The Immuno-Tex Project Proposes To Generate Tex As Cell-Free Anticancer Agents To Stimulate Anti-Cancer Immunity. Researchers Will Investigate The Mechanisms By Which Tex Are Loaded With Specific Cargo And Exploit The Cellular Machinery To Produce Immunostimulatory Tex. The Proposed Work Will Overcome The Limited Effectiveness And Resistance Linked To Certain Immunotherapies.
Funded Under
European Research Council (Erc)
Total Cost
€ 1 650 778,00
Eu Contribution
€ 1 650 778,00
Coordinated By
Klinikum Rechts Der Isar Der Technischen Universitat Munchen
Germany
