📋 Tender Overview
A Molecular Atlas Of Actin Filament Identities In The Cell Motility Machinery
Molecular Atlas Of The Actin Cytoskeleton Proteome In Migrating Cellthe Actin Cytoskeleton Is Regulated Via A Complex Interplay Between Actin-Binding Proteins (Abp), Filament Biochemistry, And Filament Geometry. Uncovering How This Interplay Defines Actin Cytoskeleton Remodelling In A Cell Migration Dynamic Would Enable A Better Understanding Of The Actin-Dependent Processes. The Erc-Funded Actinid Project Will Employ An In Situ Structural Biology Approach To Generate A Molecular Atlas Of The Actin Cytoskeleton Proteome In Migratory Cell Protrusions. Using Cryo-Electron Tomography, The Study Will Obtain 3D Imaging And High-Resolution Of The Entire Actin Networks In Cellular Protrusions. This Will Provide An Understanding Of The Reciprocal Regulation Of Abp Activity, Filament Geometry, And Biochemistry, Related To Cell Migration.
Funded Under
European Research Council (Erc)
Total Cost
€ 1 499 531,00
Eu Contribution
€ 1 499 531,00
Coordinated By
Institute Of Science And Technology Austria
Austria
