📋 Tender Overview
The Health Benefits Of Deuterium Depletion On Synaptic Function, Regional Metabolism, And Behaviour
Investigating The Health Effects Of Deuterium Depletion Waterhigh Concentrations Of Deuterium In Water Cause Mitochondrial Dysfunction. Extremely High Concentrations Can Also Lead To Cell Death. Deuterium-Depleted Water (Ddw) Appears To Represent A Safe Intervention, And Companies In The Eu Sell Ddw At Different Concentrations To The Public. However, The Positive Health Effects Of Ddw Are Not Entirely Understood. The Eu-Funded Aqua-Synapse Project Will Establish The Mechanistic Basis For The Positive Health Effects Of Ddw And Determine What Regimens Are Most Efficacious. The Project Will Apply Advanced Imaging Techniques To Measure Regional Metabolic Fluxes In The Body Of Animals In Healthy Individuals And Those Subject To Stress Following The Administration Of Ddw At Different Concentrations And For Different Periods.
Funded Under
Marie Sklodowska-Curie Actions (Msca)
Total Cost
€ 0,00
Eu Contribution
€ 763 600,00
Coordinated By
Cofac Cooperativa De Formacao E Animacao Cultural Crl
Portugal
Start Date
1 January 2023
End Date
31 December 2026
Objective
Core idea of this project is to establish the mechanistic basis for the positive health effects of deuterium depleted water and determine what regimens are most efficacious. Isotope content of drinking water has been shown affect the pathogenesis of cancers to ameliorate the stress response and reduce susceptibility to many diseases, but it remains unclear how the positive biological effects of heavy isotope reduction in drinking water are mediated. High concentrations of deuterium induce mitochondrial dysfunction, and very high concentrations can induce cell death, but the administration of deuterium at 91 ppm has antidepressant effects that were comparable to that of citalopram in a mouse model of depression. Use of deuterium depleted water appears to represent a safe intervention with few, if any, reported side effects, but it remains unclear at what concentrations the positive metabolic and behavioral effects become apparent. Companies in Europe now sell DDW at different concentrations to the public amidst a plethora of health claims that mostly lack in any sound scientific basis or safety data Thus, there is an urgent need to better understand the impact of DDW on brain and behavior at a molecular level. We will use state-of-the art imaging techniques to measure regional metabolic fluxes in the body of animals in healthy individuals throughout life and those subject to stress following the administration of DDW at different concentrations and for different periods. Also we examine how deuterium depletion affects the behaviors of neurons in vitro and electrophysiological levels and in terms of their metabolism. The project is made possible by bringing together a consortium of chemists, cell biologists, pharmacologists, imaging specialists, psychiatrists, and DDW producers for
