📋 Tender Overview
Exploring The Contribution Of Hypothalamic Gliosis To The Metabolic And Reproductive Complications Of Hypogonadism: Translational Implications For Obesity-Induced Male Hypogonadism.
Role Of Male Hypogonadism In Obesity Developmentobesity Significantly Increases The Risk Of Morbid Chronic Diseases Such As Type 2 Diabetes, Hypertension, Cardiovascular Disease, And Some Cancers. Recent Studies Suggest That Obesity Is Associated With Hypogonadism, Characterised By Low Levels Of Endogenous Testosterone That Substantially Elevates Metabolic Risk. With Funding From The Marie Sklodowska-Curie Actions Programme, The Glia-Reprobesity Project Proposes A Multidisciplinary Approach To Uncover The Potential Role Of Hypothalamic Gliosis As A Central Mechanism Linking Metabolic Dysregulation And Reproductive Dysfunction. The Project Will Use Astrocyte- And Microglia-Specific Mouse Models Of Inflammatory Signalling To Find Out The Causative Relationships Between Gliosis And Hypogonadism. These Studies Could Identify Cellular Targets For New Therapies To Decrease The Metabolic Harm From Hypogonadism And To Improve Reproductive Function.
Funded Under
Marie Sklodowska-Curie Actions (Msca)
Total Cost
€ 0,00
Eu Contribution
€ 285 140,64
Coordinated By
Universidad De Cordoba
Spain
