📋 Tender Overview
Drug-Eluting Electrical Implant To Repair The Spinal Cord
In Neurofibres (FET-PROACTIVE, 2017-2021), we accomplished a major therapeutic advance for spinal cord injury (SCI) by combining biomaterials, pharmaceuticals, and electrical stimulation into an innovative implant able to promote the closure of the spinal cord gap, with axonal regrowth and glial cell migration across large lesions in rodent and porcine models of SCI. In brief, the implant comprised biofunctionalized, conducting polymer-coated carbon microfibres (MFs) that promoted aligned neural cell growth across the lesion, embedded within a drug-eluting hydrogel that filled the tissue defect and reduced fibrosis. These intraspinal elements were complemented with electrodes that provided biphasic electrical stimulation (ES) to the lesion and the perilesional tissue, thus inducing extensive neural regeneration.
Funded Under
The European Innovation Council (Eic)
Total Cost
€ 2 646 417,50
Eu Contribution
€ 2 494 542,50
Coordinated By
Fundacion Hospital Nacional De Paraplejicos
Spain
