📋 Tender Overview
Diabetes: Pericyte-Orchestrated Islet Inflammation As A Driver Of Beta-Cell Failure
Novel Physiological Mechanism Of Beta-Cell Failure In Type 2 Diabetestype 2 Diabetes (T2D) Is Associated With Pancreatic ?-Cell Failure And Insulin Resistance. Islet Inflammation Has Been Implicated As A Driver Of T2B. The Beneficial Inflammation Linked To Insulin Secretion During Homeostasis May Later Harm ?-Cells And Impair The Glucose Response. The Erc-Funded Piin_T2D Project Will Investigate Pericyte-Orchestrated Islet Inflammation (Piin), Affected By Diabetes Risk Factors To Cause ?-Cell Failure, As A Physiological Mechanism For T2D. The Objectives Are To Study Piin In Homeostasis And Determine The Role Of T2D Environmental Risks, Such As Obesity And Aging, In The Transformation Of Islet Inflammation And ?-Cell Dysfunction. The Project Findings May Uncover Piin As A Novel Therapeutic Target For T2D Treatment.
Funded Under
European Research Council (Erc)
Total Cost
€ 2 000 000,00
Eu Contribution
€ 2 000 000,00
Coordinated By
Tel Aviv University
Israel
