📋 Tender Overview
Deciphering Cellular And Molecular Mechanisms Of ?-Cell Regeneration
Innovative Treatment To Prevent Dysfunction Of Insulin-Producing Cells In Diabetescurrently, No Drug Treatment Can Prevent The Progression Of Diabetes, Which Is Characterised By Insulin-Producing ?-Cell Dysfunction. The Insulin Inhibitory Receptor (Inceptor) Was Identified Recently As A Drug Target For ?-Cell Protection Without Insulin Side Effects. A Combination Of Glucagon-Like Peptide-1 Mediated Delivery Of Oestrogen With Insulin Therapy Might Restore ?-Cell Function. The Erc-Funded Betaregeneration Project Will Explore Novel Approaches For Targeted And Combinatorial ?-Cell Regeneration Therapy. The Inceptor Will Be Probed As The Target To Enhance ?-Cell Insulin Sensitisation, Secretion, And Function. The Project Will Also Test Monoclonal Antibodies (Both Alone And As Drug Conjugates) For ?-Cell Protection And Regeneration. The Goal Is To Find If Combinatorial Treatment Can Stop ?-Cell Loss And Dysfunction.
Funded Under
European Research Council (Erc)
Total Cost
€ 2 446 645,00
Eu Contribution
€ 2 446 645,00
Coordinated By
Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt Gmbh
Germany
