📋 Tender Overview
The glass slides used to prepare samples for looking at under a microscope have hardly changed in the nearly 200 years since their invention. Breaking with tradition two scientists from EPFLs Institute of Microengineering in Neuchtel have developed a new type of microscope slide that enables early-stage diagnosis of some types of cancer. Used in millions of labs around the world for microscopic observations glass slides have the major drawback of reducing usable light by 70 making many compounds hard or impossible to detect. At EPFLs Institute of Microengineering in Neuchtel materials chemist Raphal Barbey and optical engineer Nicolas Descharmes have developed a new type of glass slide that can boost the amount of light in fluorescence microscopy by a factor of up to 25. This means that in an ideal case these revolutionary slides would be able to detect the presence of one molecule where 25 molecules would be needed on conventional slides.Unique optical propertiesThe new slides have a layered structure that is capable of controlling the electromagnetic environment surrounding the samples. When light is shined on the fluorophores in a sample they emit more light than they would on a conventional slide and all of that light is directed towards the microscopes detector. This results in clearer faster better images.Enabling early-stage diagnosisDescharmes and Barbeys invention could enable the early-stage diagnosis of some types of cancer and autoimmune diseases as well as the easier reading and archiving of histopathology slides. The duo is currently working on industrializing the production of their patented technology in collaboration with CSEM the Swiss Center for Electronics and Microtechnology.
